User Settings
Article10.1093/joneph/23.5.514

Vitamin D receptor activators and response to injury in kidney diseases

Theodoros Eleftheriadis,Georgia Antoniadi,Vassilios Liakopoulos,Nikolaos Antoniadis,Ioannis Stefanidis,G. Galaktidou-2010-09-01-Journal of Nephrology
13

TL;DRAbstract

Clinical studies have confirmed that administration of vitamin D receptor (VDR) activators offers a survival benefit in hemodialysis patients and may help in preservation of renal function in predialysis patients. Accumulated clinical and mainly experimental data support that in the context of kidney disease, VDR activators exert their beneficial effect not only due to their action on calcium and phosphorus homeostasis, but also through modulation of the response to injury. They attenuate systemic and renal inflammation, and they affect the tissue repair process, reducing renal fibrosis. This aspect of the functions of VDR activators in kidney disease is reviewed in the present manuscript.

Chat with Paper

AI Agents for this Paper

Clinical studies have confirmed that administration of vitamin D receptor (VDR) activators offers a survival benefit in hemodialysis patients and may help in preservation of renal function in predialysis patients. Accumulated clinical and mainly experimental data support that in the context of kidney disease, VDR activators exert their beneficial effect not only due to their action on calcium and phosphorus homeostasis, but also through modulation of the response to injury. They attenuate systemic and renal inflammation, and they affect the tissue repair process, reducing renal fibrosis. This aspect of the functions of VDR activators in kidney disease is reviewed in the present manuscript.

Keywords

MedicineCalcitriol receptorVitamin D and neurologyKidney diseaseNephrologyContext (archaeology)KidneyFibrosis

Chat

Click to start Chat