Studies on some lipids of clinical interest

TL;DRAbstract

Chapter I reports studies on a number of common drugs and metabolites, some of which were found to affect lipids. Quantitative studies of drug‚ÄövÑvÆinduced release of cholesterol esters from lipoproteins in vitro are described. Tetracycline was found to act an both lipoproteins and proteins, causing marked denaturation of the latter and a strong delipidation of the former. Similar effects were noted in the cases of Atromid S and Phenformin. These drugs were also reacted with serum in combination with magnesium lactate alone, and in combination with pyridoxine, and in the latter case some enhancement of delipidating effects were seen. Similar tests on a number of amino acids were negative. Spectrophotometric, electrophoretic and immunoelectrophoretic investigations of the type and degree of binding of tetracycline and nitrofurantoin to serum proteins are reported in Chapter II. Competitive binding of tetracycline with displacement of lipids from their binding sites support the findings

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