The Collection and Data-Driven Analyses of Proteins Localized to Nuclear Compartments

TL;DRAbstract

The cell nucleus is a complex yet dynamic organelle with many morphologically distinct nuclear compartments. Some nuclear compartments are hypothesized to play important regulatory roles. For example, the chromatin is primarily concerned with DNA replication, the nuclear speckle accumulates pre-messenger RNA (pre-mRNA) splicing factors at actively transcribed genes, and the nucleolus controls the ribosome subunit biogenesis in the cell nucleus. Once the entire complement of proteins for the cell nucleus has been defined, the relationships and interactions between proteins and biological processes within the nucleus can be systematically understood. Nuclear protein data however are not readily accessible from a single resource, but instead documented in multiple papers and repositories. Therefore, in this thesis, several objectives are proposed: firstly, to collect a high-confidence set of nuclear proteins with known nuclear compartment associations and utilize the set to obtain a bette

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