sP (EO-stat-PO) - glycosaminoglycans (GAGs) hybrid-hydrogels for medical applications

TL;DRAbstract

The primary focus of this work is to develop a highly stable hydrogel system as a depot for drug delivery and as material for tissue engineering scaffolds. Two separate cross-linkers namely six arm star shaped (EO-stat-PO) prepolymers with isocyanate endgroups [NCO-sP(EO-stat-PO)] and six arm star shaped (EO-stat-PO) prepolymers with acrylate endgroups [Acr-sP(EO-stat-PO)] were prepared to gel unmodified and thiol-modified bio-polysaccharides respectively. In particular we discuss three types of hydrogel systems for the above mentioned bio-applications namely, hydrogels formed by gelation of NCO-sP(EO-stat-PO) only, i.e., the hydrogel system-1, hydrogel formed by addition of hyaluronic acid to NCO-sP(EO-stat-PO), i.e. the hydrogel system-2 and hydrogel formed by addition of thiol-modified hyaluronic acid to Acr-sP(EO-stat-PO), i.e. the hydrogel system-3. Different than hydrophobic particles or layers, hydrogels are open to water. Water molecules can diffuse in and out and thus extract

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