User Settings
Article10.1212/wnl.84.14_supplement.p2.010

Diabetic neuropathy and the sensory neuron: new molecular targets (P2.010)

Masaki Kobayashi,Chu Cheng,Cristiane de la Hoz,Douglas W. Zochodne-2015-04-06-Neurology
2

TL;DRAbstract

OBJECTIVE: To explore new pathways and molecules that contribute to experimental diabetic neuropathy and sensory neuron degeneration. BACKGROUND: Polyneuropathy involving sensory neurons is a common complication of diabetes mellitus that may target neuron gene output and function. Cajal bodies (CBs), nucleoli and nuclear speckles are unique nuclear bodies known to be altered with the changes of mRNA metabolism in stress conditions. CB colocalizes with SMN, the depletion of which is responsible for motor neuron degeneration in spinal muscular atrophy. Nuclear speckles colocalize with CWC22, which is an essential pre-mRNA splicing factor. DESIGN/METHODS: We analyzed L4 and L5 dorsal root ganglion (DRG) sensory neurons in a 16 week model of type 1 (STZ) diabetes in C57BL/6 mice with experimental neuropathy. Methods included DRG gene expression microarray, behavior, electrophysiology, and immunohistochemistry. Diabetic mice were treated by near nerve and intraplantar injection of siRNA to

Chat with Paper

AI Agents for this Paper

OBJECTIVE: To explore new pathways and molecules that contribute to experimental diabetic neuropathy and sensory neuron degeneration. BACKGROUND: Polyneuropathy involving sensory neurons is a common complication of diabetes mellitus that may target neuron gene output and function. Cajal bodies (CBs), nucleoli and nuclear speckles are unique nuclear bodies known to be altered with the changes of mRNA metabolism in stress conditions. CB colocalizes with SMN, the depletion of which is responsible for motor neuron degeneration in spinal muscular atrophy. Nuclear speckles colocalize with CWC22, which is an essential pre-mRNA splicing factor. DESIGN/METHODS: We analyzed L4 and L5 dorsal root ganglion (DRG) sensory neurons in a 16 week model of type 1 (STZ) diabetes in C57BL/6 mice with experimental neuropathy. Methods included DRG gene expression microarray, behavior, electrophysiology, and immunohistochemistry. Diabetic mice were treated by near nerve and intraplantar injection of siRNA to

Keywords

MedicineSensory systemSensory neuropathySensory neuronNeuroscienceInternal medicinePsychology

Chat

Click to start Chat