Therapeutic intervention in Alzheimer's disease

TL;DRAbstract

Alzheimer's disease (AD) results from a series of dysfunctions which spread throughout the cortex in a precise spatiotemporal manner, and which subsequently give rise to a characteristic pattern of cognitive and non-cognitive symptoms. Whilst some of these symptoms can be controlled with specific drug regimes, there are still no treatments available to prevent the disease. Similarly, there are no drugs available which will reverse or even halt the progression of the pathological changes which occur in the AD brain. It is hypothesised that ˜í‚â§-amyloid deposited within the brain as \plaques' causes slowly evolving physical damage to neurons which then triggers a stereotypical neuronal response to trauma. This involves specific cytoskeletal alterations which give rise to the characteristic neuropathology of AD and which can be experimentally modeled in both in vivo and in vitro models of neuronal injury. That the pathogenesis of AD crucially involves the cytoskeleton and that targeting

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