TH‐AB‐304‐01: Dose‐Volume Relations for Late Rectal Bleeding in 1001 Patients From Five Prostate Cancer Cohorts

TL;DRAbstract

Purpose: Normal tissue complications following radiotherapy (RT) are commonly estimated from single institutions, limiting generalizability of critical dose‐volume thresholds. In this study we use data from five cohorts/institutions to explore dose‐volume relations for late rectal bleeding (LRB) after RT for prostate cancer. Methods: The investigated cohorts included 1001 patients treated with various RT techniques for prostate cancer (922 3DCRT, 211 image‐guided RT, and 79 intensity‐modulated RT patients) to 70–86 Gy@2Gy/fraction in 1991–2007. The rectum extended from the recto‐sigmoid flexure to the anal canal, and the median (range) follow‐up for LRB was 58 (4–259) months. Rectal cross sectional area, length, and volume were compared between LRB and non‐ LRB patients (Mann‐Whitney‐test). The ability of dose metrics to predict moderate‐to‐severe LRB (prevalence: 14%) was investigated on univariate analysis, UVA, (Spearman's Rho (Rs) and p‐values calculated as medians from 10 0000 Boo

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