Multiple Evolutionary Solutions to Core Histone Gene Regulation

TL;DRAbstract

Core histones are one of the most conserved protein families known. The patterns of core histone gene expression are also highly similar among distantly related eukaryotic species. Core histone genes from Saccharomyces cerevisiae and Schizosaccharomyces pombe , as well as the more distantly related Homo sapiens , are subject very specific cell‐cycle regulation that leads to expression peaking in S‐phase. Although a number of core histone cis‐regulatory elements have been identified across model eukaryotic organisms, little is known about the mechanisms underlying the evolution of these cis‐binding sites and how these result in the highly conserved expression phenotype. We explore the evolution of 14 experimentally verified core histone cis‐regulatory elements and compare their evolution to core histone protein sequence evolution among 24 different species. The core histone cis‐elements, on the other hand, show a pattern of lineage‐specific evolution with elements from the same, or simi

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