The Reno-Protective Effect of Ethanolic Extract of Cassia Fistula (Amaltas) Leaves on Streptozotocin Induced Diabetic Nephropathy in Rats

TL;DRAbstract

Objective: To determine the Reno-protective effect of ethanolic extract of Cassia fistula (Amaltas) leaves on streptozotocin induced diabetic nephropathy in rats. Study Design: An animal experimental study Place of Study: The study was done in Biochemistry department, Islamic International Medical College,Rawalpindi and NIH.Islamabad. Materials and Methods: Single injection of STZ was given intraperitoneally to rats and those rats that showed fasting blood glucose level over 280mg/dl were included in the study. After induction of diabetes all rats were divided into, normal control group (A), diabetes positive control group (B), and the two groups (C and D) served as experimental groups while group E served as standard as it received glibenclamide. Group C and D diabetic experimental rats received ethanolic extract of Cassia fistula leaves at 400 mg/kg and 500mg/kg of body weight orally for eight weeks on daily basis. On the other hand group E rats received glibenclamide at 0.5 mg/k

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