Acoustic droplet vaporization

TL;DRAbstract

Current tumor chemotherapy is associated with severe side effects caused by adverse effects of the drugs on healthy tissue. A local delivery of the drug has the advantage of a more controlled biodistribution of the therapeutic agent, which will reduce the side-effects, and offers the potential to use a higher concentration which will improve therapeutic efficiency. Recent studies have shown that liquid emulsion microdroplets of a size of 10 μm composed of a low-boiling point perfluorcarbon (PFC) have the potential to be a highly efficient system for local drug delivery. Moreover, nanodroplets of a size of 100 nm can extravasate through the leaky vessels of a tumor and the drug can be released upon triggering with diagnostic ultrasound while an explosive evaporation of the droplet takes place. We use ultra-high speed optical imaging to study, for the first time, acoustic droplet vaporization dynamics at nanoseconds timescales. We develop a simple theoretical model to capture all of the

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