TL;DRAbstract
3-Amino-triazole-5-carboxylic acid was proposed by acylating and cyclizating in condition of aminoguanidine and oxalic acid. Factors were investigated including the material ratio, mother liquor, reaction temperature and water consumption. The yield and purity of 3-Amino-triazole-5-carboxylic acid were 76.8% and 95.67% respectively under the optimal conditions: n(oxalicacid):n(aminoguanidine)=1.3:1, mother liquor was applied twice, sulfuric acid was completed dropping 1 h at 60 ℃ and m(acylation):m(water consumption)=1:5. The synthetic compounds were characterized by IR, 1H NMR and mass spectra.
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3-Amino-triazole-5-carboxylic acid was proposed by acylating and cyclizating in condition of aminoguanidine and oxalic acid. Factors were investigated including the material ratio, mother liquor, reaction temperature and water consumption. The yield and purity of 3-Amino-triazole-5-carboxylic acid were 76.8% and 95.67% respectively under the optimal conditions: n(oxalicacid):n(aminoguanidine)=1.3:1, mother liquor was applied twice, sulfuric acid was completed dropping 1 h at 60 ℃ and m(acylation):m(water consumption)=1:5. The synthetic compounds were characterized by IR, 1H NMR and mass spectra.
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