Mass spectral investigations of boron neutron capture therapy (BNCT) agents

TL;DRAbstract

We examined the use of mass spectrometry incorporating fast atom bombardment ionization to determine if the potential existed for the development of a HPLC FAB/MS analytical procedure utilizing the new continuous-flow FAB inlet. All experiments were conducted on a KRATOS MS890 equipped with an 8 kV MS50-type FAB source. The MS890 was equipped with an Ion Tech (11NF) saddle field ion gun and xenon was used as the FAB gas. Initial experiments using BSH were conducted in both positive and negative ion modes using a variety of FAB matrices. Positive ion experiments were discontinued when no peaks indicative of the compound of interest were observed. The positive ion spectra were dominated by peaks arising from sodium reacting with the various matrices used. Experiments conducted in the negative ion mode proved to be much more productive. A variety of matrices were tested with BSH. These matrices included glycerol, thioglycerol, 3-nitrobenzyl alcohol, triethanolamine, and PEG-600. No peaks

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