Commensal bacteria and T cells control the generation of memory NK cells (P6103)

TL;DRAbstract

Abstract Previously, only T and B cells were thought able to generate long-lived memory cells; however, recent studies demonstrated that natural killer (NK) cells expressing the activating Ly49H receptor undergo clonal expansion, contraction, and generate long-lived memory cells after infection with mouse cytomegalovirus (MCMV). It is still unclear which subsets of NK cells preferentially give rise to memory NK cells. In this study, we show that expression of killer cell lectin-like receptor G1 (KLRG1) defines short-lived effector cells and precursor for long-lived memory cells. We found that sorted KLRG1-, but not KLRG1+ NK cells can generate memory cells. Interestingly, the percentage of KLRG1+ NK cells is significantly increased in Rag1-/- mice and Rag1-/- NK cells are largely impaired in the generation of memory cells. This phenotype was rescued by mixed bone marrow chimeric (wild-type:Rag1-/-) mice. Notably, the same results were also demonstrated in Tcra-/- or T cell-depleted mic

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