Vitamin D, Inflammation, and Relations to Insulin Resistance in Morbidly Obese Pre-Menopausal Women

TL;DRAbstract

Vitamin D has traditionally been known to involve in calcium homeostasis and prevent rickets; recently it has been recognized to inversely associate with many non-skeletal diseases and conditions including obesity and type 2 diabetes. In vitro studies demonstrated that vitamin D possesses anti-inflammatory properties. It remains unknown if the effect of vitamin D on insulin sensitivity is mediated by suppressing inflammation in human adipose tissues. \nObese women (n=76) approved for bariatric surgeries at UIC medical center were recruited. 2-hour oral glucose tolerance test was performed; insulin sensitivity was assessed. mRNA expression of vitamin D receptor (VDR), CD68, collagen VI and various inflammatory genes in visceral (VAT) and subcutaneous adipose tissues (SAT) were assessed.\n82% of the subjects were normal glucose tolerance. Nearly 90% of our subjects were vitamin D adequate. There was no association between 25OHD and insulin sensitivity, CRP and IL6. When analysis was rest

Chat with Paper

AI Agents for this Paper