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Open AccessDissertation10.5287/ora-6r62n2gm9

Radiolabelled copper complexes for cancer imaging

Rebekka Hueting-2011-01-01-Oxford University Research Archive (ORA) (University of Oxford)
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TL;DRAbstract

<b>Chapter One</b> introduces molecular imaging and the modalities available for oncological imaging. The radioisotopes and imaging agents for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are discussed together with the bifunctional chelator approach for radiolabelling of biomolecules. Finally, the chemistry and radioisotopes of copper are described, and copper bis(thiosemicarbazonato) complexes introduced in the context of PET imaging. <b>Chapter Two</b> describes the synthesis and characterisation of novel carboxylate- and maleimidefunctionalised bis(thiosemicarbazonates) and their conjugation to biologically active molecules. Radiolabelling of a chelator-bombesin conjugate demonstrated site-specific labelling at room temperature and preliminary in vitro and in vivo studies confirmed its potential as an imaging agent. Bioconjugation to a model protein and subsequent radiolabelling was also investigated. <b>Chapter Three</b> introduces mole

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<b>Chapter One</b> introduces molecular imaging and the modalities available for oncological imaging. The radioisotopes and imaging agents for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are discussed together with the bifunctional chelator approach for radiolabelling of biomolecules. Finally, the chemistry and radioisotopes of copper are described, and copper bis(thiosemicarbazonato) complexes introduced in the context of PET imaging. <b>Chapter Two</b> describes the synthesis and characterisation of novel carboxylate- and maleimidefunctionalised bis(thiosemicarbazonates) and their conjugation to biologically active molecules. Radiolabelling of a chelator-bombesin conjugate demonstrated site-specific labelling at room temperature and preliminary in vitro and in vivo studies confirmed its potential as an imaging agent. Bioconjugation to a model protein and subsequent radiolabelling was also investigated. <b>Chapter Three</b> introduces mole

Keywords

CopperCancer imagingChemistryCancerCancer researchMedicineInternal medicineOrganic chemistry

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