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Article10.1161/circ.124.suppl_21.a8963

Abstract 8963: Role of Caveolin-Centered Adiponectin Signalsome and Neutral Ceramidase in Adiponectin's Anti-Inflammatory, Anti-Oxidative and Anti-Nitrative Signaling

Yajing Wang,Xiaoliang Wang,Wayne Bond Lau,Yuexing Yuan,Wei Yi,Yang Sun+4 more-2011-11-22-Circulation
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TL;DRAbstract

Endothelial and vascular protective actions of adiponectin (APN) are well-recognized, but its underlying transmembrane and intracellular signaling remain largely unknown. Recently, we demonstrated that caveolin plays an essential role in the formation of a membrane-situated APN signalsome containing adiponectin receptor (AdipoR), APPL1, and adenylate cyclase (AC). However, the significance of this signalsome in APN vascular biology has not been investigated. Moreover, a very recent study suggested that AdipoR may function as a neutral ceramidase. However, the pathological importance of APN-activated ceramidase in APN’s vascular protective action remains completely unknown. Our current study investigated the relationship between caveolin-1 (Cav1) and ceramidase in APN’s anti-inflammatory, anti-oxidative, and anti-nitrative actions. Pre-treatment of HUVECs with APN (2 µg/ml) significantly increased ceramidase activity (3.7-fold, P<0.01), and decreased TNFα-induced ICAM-1 expression (P

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Endothelial and vascular protective actions of adiponectin (APN) are well-recognized, but its underlying transmembrane and intracellular signaling remain largely unknown. Recently, we demonstrated that caveolin plays an essential role in the formation of a membrane-situated APN signalsome containing adiponectin receptor (AdipoR), APPL1, and adenylate cyclase (AC). However, the significance of this signalsome in APN vascular biology has not been investigated. Moreover, a very recent study suggested that AdipoR may function as a neutral ceramidase. However, the pathological importance of APN-activated ceramidase in APN’s vascular protective action remains completely unknown. Our current study investigated the relationship between caveolin-1 (Cav1) and ceramidase in APN’s anti-inflammatory, anti-oxidative, and anti-nitrative actions. Pre-treatment of HUVECs with APN (2 µg/ml) significantly increased ceramidase activity (3.7-fold, P<0.01), and decreased TNFα-induced ICAM-1 expression (P

Keywords

AdiponectinMedicineOxidative phosphorylationInflammationInternal medicineEndocrinologyPharmacologyBiochemistry

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