Frekuensi polimorfisme gen interleukin-6 174 G/C pada pasien hipertensi esensial :: Studi pada populasi hipertensi dan normotensi di Kecamatan Mlati Yogyakarta

TL;DRAbstract

Some research has been reported that there is a relationship between blood pressure and inflammatory process. Interleukin 6 (IL-6) is one of the cytokines that play a role in the process of inflammation and tissue damage that would affect blood pressure. Gene polymorphism in IL-6 promoter 174 G/C effect the transcription and IL-6 levels in the blood. The purpose of this research is to see the relationship of genetic variation of gene polymorphisms of IL-6 174G / C with incident of hypertension. Case-control design Research was conducted with 51 samples of essential hypertension that age and gender matched control group. Polymorphism and IL-6 gene examined with polymerase chain reaction to genotype in the gene IL-6. The genotype distribution for GG 50 patients (98%) in essential hypertension group and 48 (94,1%) in normal group. Genotype GC 1 (2%) in essential hypertension group and 3 (5,9%) in normal group In this study the genotype CC was not found. From the statistic analysis there i

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