Quorum-sensing-dependent regulation of staphylococcal virulence and biofilm development

TL;DRAbstract

Staphylococci are a genus of bacteria remarkably adept at causing a variety of human and animal diseases. These range from relatively benign skin infections, such as impetigo, to much more serious ones, including endocarditis, osteomyelitis, toxic shock syndrome, and those associated with implanted medical devices. In fact, the staphylococci are a leading cause of nosocomial infections worldwide, and the continuing emergence of highly drug-resistant strains has created an immediate need for the development of new antimicrobial therapies and strategies. Since the identification of the accessory gene regulator (Agr) quorum sensing system in Staphylococcus aureus, and subsequently in other staphylococcal species, it has been assigned a central role in the regulation of staphylococcal virulence. As such, it has attracted substantial attention as a potential target for controlling staphylococcal disease.

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