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Article10.1096/fasebj.21.6.a1195-c

EFFECTS OF SUCROSE FEEDING ON RENAL SODIUM AND WATER TRANSPORTER ABUNDANCE AND SYSTEMIC BLOOD PRESSURE

Raphael Ribeiro de Aquino Freitas,Carolina Ribeiro Barreto,Elizabeth Barbosa Oliveira‐Sales,M. A. Boim,Cássia T. Bergamaschi,Miriam Sterman Dolnikoff+1 more-2007-01-01-The FASEB Journal
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TL;DRAbstract

There is a relationship between sucrose feeding and arterial hypertension. Dysregulation of sodium and/or water reabsorption by the kidney may contribute to hypertension. The objective of this study was to investigate, in rats with overload of sucrose in diet, the effect on creatinine clearance (CCl), fractional excretion of Na+ (FENa), fractional excretion of K+ (FEK) and alterations in the mRNA expression levels of the kidney. Wistar rats (150–180g) were treated for 30 days with sucrose solution (20%) instead of drink water (SC; n=7), the control group (C; n=8) had tap water ad libitum. Mean arterial pressure (MAP), were recorded “on line” in a Power Lab system. The mRNA expression levels of epithelial sodium channel (ENaC) and water channel protein (AQP2) were analyzed in the cortical kidney tissue by Real Time RT-PCR technique. A significant (P<0.05) increase in MAP was observed in SC (128±1mmHg) compared with C (102±4 mmHg). The following values for renal function parameters were

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There is a relationship between sucrose feeding and arterial hypertension. Dysregulation of sodium and/or water reabsorption by the kidney may contribute to hypertension. The objective of this study was to investigate, in rats with overload of sucrose in diet, the effect on creatinine clearance (CCl), fractional excretion of Na+ (FENa), fractional excretion of K+ (FEK) and alterations in the mRNA expression levels of the kidney. Wistar rats (150–180g) were treated for 30 days with sucrose solution (20%) instead of drink water (SC; n=7), the control group (C; n=8) had tap water ad libitum. Mean arterial pressure (MAP), were recorded “on line” in a Power Lab system. The mRNA expression levels of epithelial sodium channel (ENaC) and water channel protein (AQP2) were analyzed in the cortical kidney tissue by Real Time RT-PCR technique. A significant (P<0.05) increase in MAP was observed in SC (128±1mmHg) compared with C (102±4 mmHg). The following values for renal function parameters were

Keywords

EndocrinologyInternal medicineChemistryRenal functionReabsorptionSodiumKidneyFractional excretion of sodium

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