Fatty acid-binding protein as plasma marker for tissue injury

TL;DRAbstract

Biochemical markers have become important diagnostic and prognostic parameters in the management of patients with acute tissue injury.One of the novel and promising markers is cytoplasmic fatty acid-binding protein (FABP).This small (15 kD) protein is involved in cellular long-chain fatty acid metabolism and is abundantly expressed in tissues with an active fatty acid metabolism like heart and liver.Following cell damage, FABP is rapidly released into the interstitium and plasma.In this review, studies in the fields of acute coronary syndromes, kidney-and liver transplantation, intestinal ischemia and brain injury are evaluated on the use of FABP as marker for tissue injury detection.Tissue contents and clinical utility of different FABP-types have been reported and indicate that an early release and the sensitive detection of tissue injury are unique features of FABP over other marker proteins.The combined data indicate that monitoring of specific FABP types in plasma can help decreas

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