Anti-Tumour Promoting Activity of Selected Malaysian Vegetables and Fruits, and Identification of Anti-Tumour Promoting and Antioxidant Compounds from Coleus Tuberosus, Benth (Ubi Kemili)

TL;DRAbstract

A convenient short-term in vitro assay, the inhibition of Epstein-Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium n- butyrate was conducted to detect the naturally occurring anti-tumour promoters of 133 vegetables and fruits. Forty-two plants showed strong inhibitory activity, 33 plants showed moderate inhibitory activity, 21 plants were found to be weakly active and 37 plants were inactive. Coleus tuberosus, Benth was chosen for further study because it showed the strongest activity. Phytosterols (CT 1) and 2a,3p.dihydroxyl-12-oleanen-28-oic-acid (CT 2) were isolated from Coleus tuberosus, Benth based on bioassay-guided fractionation. CT 1 was identified as a mixture consisting of stigmasterol (32.0%), campesterol (27.7%) and β-sitosterol (40.3%) by gas chromatography. CT 2 was established as 2a,3p.dihydroxy- 12-oleanen-28-oic acid Five plants that showed the highest anti-tumour promoting activity namely, Carica papaya, Ba"ingtonia macrostachya,

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