Simultaneous Analysis of Germline Crips and Snips in High Risk Prostate Cancer Families

TL;DRAbstract

Prostate cancer is the leading cancer among men in the United States, and is a disease with strong genetic susceptibility. The genetic susceptibility is due to the inheritance of altered germline DNA sequences, either in the form of point mutations such as single nucleotide polymorphisms (SNPs), or deletions/gains of a string of nucleotides such as copy number polymorphisms (CNPs). Most current genetic studies focus only on the role of SNPs in genetic susceptibility. In contrast, few studies have explored the role of deletions/gains in cancer predisposition, due to limited methods. In fact, germline deletions/gains are common in the human genome and may have a significant impact on gene products because they can involve an entire gene or a significant portion of a gene. They may play a more important role in hereditary PCa, a type of PCa that is likely due to germline changes in major genes. With the grant support, we have made important progresses toward this new research area. To our

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