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Advanced diffusion MRI of brain tissue and applications in neurological research

Ezequiel Farrher,N. Jon Shah-2013-01-01-RWTH Publications (RWTH Aachen)
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TL;DRAbstract

This work deals with the analysis of water diffusion in model and in vivo brain tissues by means of the DW MRI technique. Biological tissues in general, and the human brain in particular, represent systems of highly complex architecture that give rise to very complex diffusion behaviour of water. The random movement of water molecules appears restricted or hindered, leading to a reduction in the measured molecular diffusivity and deviations from the Gaussian diffusion behaviour. Due to the highly complex DW MRI signal response, different problems arise regarding the validation and modelling of the experimental data. Therefore, artificial systems, or "phantoms", that mimic the relevant tissue properties, but with reduced complexity and well-known structure and physical properties, are becoming an important tool in the field. The original research presented in this work can be divided into two parts. The first part deals with the development of new artificial diffusion phantoms that may

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This work deals with the analysis of water diffusion in model and in vivo brain tissues by means of the DW MRI technique. Biological tissues in general, and the human brain in particular, represent systems of highly complex architecture that give rise to very complex diffusion behaviour of water. The random movement of water molecules appears restricted or hindered, leading to a reduction in the measured molecular diffusivity and deviations from the Gaussian diffusion behaviour. Due to the highly complex DW MRI signal response, different problems arise regarding the validation and modelling of the experimental data. Therefore, artificial systems, or "phantoms", that mimic the relevant tissue properties, but with reduced complexity and well-known structure and physical properties, are becoming an important tool in the field. The original research presented in this work can be divided into two parts. The first part deals with the development of new artificial diffusion phantoms that may

Keywords

Brain tissueDiffusion MRIMedicineDiffusionComputer scienceNeuroscienceMagnetic resonance imagingBiomedical engineering

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