Novel aspects of Na+,K+-ATPase

TL;DRAbstract

<p>Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation.</p><p>It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. New findings in this study are: 1) the level of intracellular Ca 2. concentration determines the functional effects of PKA and PKC-mediated Na,K-ATPase phosphorylation. At low [Ca 2+]i, activation of PKA or PKC resulted in inhibition of Na,K-ATPase activity, while at high (Ca 2+]i a stimulatory effect was observed. 2). Dynamic regulation of Na,K-ATPase activity plays a functional role in striatal neurons. Activation of D1 subtype of dopamine receptors resulted in inhibition of Na,K-ATPase activity. An additional unexpected and intriguing finding was colocalization of DI and D2 subtypes of dopamine receptors in virtually all striatal neuro

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