Amino acid-induced thermogenesis during anaesthesia

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<p>General anaesthesia causes hypothermia due to decreased metabolic rate and impaired thermoregulation. Adverse effects of hypothermia are coagulation disorders, wound infection, ischemic cardiac events and postoperative shivering. Many warming devices are in use to prevent heat loss, but little attention is paid to stimulate the body's own heat generation. All nutrients raise energy expenditure, and the highest diennic effect is ascribed to amino acids and proteins, 30-40 % in the awake state. In patients with complete cervical spinal cord injury and disrupted nervous connections between the brain and periphery, a normal thermogenesis was found in response to amino acids, indicating that central sympathetic nervous activation is not obligatory for amino acid-induced thermogenesis. It was suggested that nutrients stimulate heat production in peripheral tissues. The present studies were performed in order to determine if amino acids were able to exert diennogenic stimulation also

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