Investigations of complement resistance factors in Leishmania chagasi

TL;DRAbstract

46 Introduction 47 Materials and Methods 48 Results and Discussion 49 Acknowledgments 51 References 51 Figures 52 CHAPTER 4: Trans-effects of leishmania vector cLHYG on Major Surface Protease (MSP) RNA and protein expression in high passage Leishmania chagasi 55 Introduction 55 Materials and Methods 56 Results 59 Discussion 63 References 65 Figures 68 CHAPTER 5: General Conclusions 73 APPENDIX I 75 Further characterization of cosmid 51 deletion constructs 75 Characterization of complement assays and time course experiments 78 Figures 80 ACKNOWLEDGEMENTS 87

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