Effects of the angiotensin II type 1 receptor blocker (AT₁ receptor blocker) candesartan cilexetil on systemic and renal haemodynamics in hypertensive patients

TL;DRAbstract

Established primary hypertension is primarily characterised by elevated peripheral resistance and an increase in renal vascular resistance. Antagonism of angiotensin II may be a particularly relevant intervention in this condition, as angiotensin II is known to act both as a powerful vasoconstrictor and as a stimulus to vascular hyperthrophy.The aims of this study were to: - evaluate the acute and long-term effects of 16 mg candesartan cilexetil o.d., an angiotensin II type 1 (AT1) receptor blocker, on systemic and renal haemodynamics and RAAS hormones in patients with mild and moderate hypertension, - assess the long-term effects on forearm haemodynamics and baroreceptor sensitivity and, finally, - compare the effects of candesartan cilexetil 16 mg with the effects of losartan 50 mg and valsartan 80 mg on blood pressure, renal haemodynamics and RAAS hormones before and during intravenous angiotensin II infusion. Blood pressure was assessed intra-arterially and by ordinary mercury mano

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