Surface Studies on the Structure and Functionality of Bioactive Materials.

TL;DRAbstract

Bioactive materials are critical in many applications in the fields ranging from antibiofouling coatings to tissue engineering to biosensing devices. The construction of bioactive materials generally involves dispersion of bioactive components such as biocides, peptides or proteins in organic or inorganic matrices. However, when these bioactive components are incorporated to such matrices, their functionalities may be significantly hindered. As a result, it has spurred great attention seeking guidelines for future rational design and development of bioactive materials with optimal functionalities. This thesis proposes optimization strategies by investigating interfacial molecular interactions of various bioactive materials in situ using surface specific spectroscopies and correlating the structural and orientational information to their activity. Firstly, two biocide-incorporated antifouling polymeric materials are characterized using sum frequency generations vibrational spectroscopy

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