Bioadhesion and strength of attachment of neurons to biomaterials, pyrolytic carbon and commercially pure titanium, subjected to radio frequency glow discharge and autoclave sterilization

TL;DRAbstract

Improved electrically conductive biomaterials, that minimize or eliminate encapsulation by fibrous tissue from the generally seen “foreign body reaction”, would be beneficial for longer-term reliability of neural electrode stimulation and signal recording functions. Improved soft tissue adhesion and integration with electrode surfaces could favor better electronic signal transfer while also preventing micromotion of the electrodes near and beyond target tissue sites. This investigation selected two conductive biomaterials with good prior records of long-term implant biocompatibility. These included pyrolytic carbon (PyC) as used in synthetic heart valves, and commercially pure titanium (cpTi) as used in osseointegrating dental implants. Surface energy modification by low-temperature sterilizing Radio Frequency Glow Discharge treatment (RFGD) was utilized to obtain better neural cell adhesion strengths. A dense cell-to-substratum implant/microtissue adhesion model was developed by 48-ho

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