The application of antibodies in optical and electrochemical transduction processes

TL;DRAbstract

Chapter 1 relates the background information of the structure of antibodies, the nature of their interaction with antigen and their production as polyclonal antibodies. Examples of antibodies which have been produced against luminescent molecules are given and it is illustrated how the specific interaction of antibodies with luminescent complexes can be used to gain information on the structure, function and rotational dynamics of antibodies. The principle features of immunoassays are outlined with a focus on amperometric immunosensing including some areas of active research within amperometric immunosensing. This serves as a general introduction to Chapter 4; the development of an amperometric immunosensor based on single wall carbon nanotubes.\n\nChapter 2 begins with a review of the fundamental chemical, photochemical and electrochemical properties of Ru(II) and Os(II) polypyridyl complexes. It is shown how their photophysical properties can be modulated by the interaction of the co

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