Structure elucidation of biomedically relevant marine cyanobacterial natural products

TL;DRAbstract

The use of natural products for the treatment of disease has been an age-old practice. With chemical diversity, structural complexity, and perceived ecologic roles in chemical defense, natural products, not surprisingly, continue to serve as inspiration for pharmaceutical lead compounds. In that spirit, this dissertation further delineates the novel chemistry of marine natural products by describing bioassay-guided isolation and structure elucidation of cyanobacterial secondary metabolites with efficacy against several targets of human disease. Chapter I presents a rationale for the dissertation research by providing a general introduction of marine natural products chemistry and drug development as it relates specifically to cyanobacteria. Chapter II describes the isolation, structure elucidation, and anti-inflammatory activity of malyngamide 2, a nitric oxide inhibitor. Chapter III explores bioassay-guided fractionation and structure elucidation of hoiamide D, a cyanobacterial derive

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