Interaction of<i>Candida albicans</i>with Phagocytes

TL;DRAbstract

One of the central players in antifungal immunity is phagocytic cells. Recognition by these cells leads to fungal uptake and killing and the induction of an inflammatory response. The increased risk of fungal infection resulting from perturbations in the levels of the number of phagocytes emphasizes the importance of these cells in the control of mycoses. This chapter covers the mechanisms that phagocytic cells use to recognize, ingest, and kill this pathogen, as well as those mechanisms involved in the induction of inflammatory and adaptive response to these organisms. Although involving multiple interactions with multiple receptors, different phagocytes appear to utilize different combinations of receptors to recognize Candida. Recognition of Candida leads to ingestion of the fungus through the actin-dependent process of phagocytosis. The uptake of Candida involves several different phagocytic mechanisms which depend on the cell type, presence of opsonins, and the morphological form

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