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Article10.1096/fasebj.22.2_supplement.169

Involvement of the Nucleus Raphe Obscurus (ROb) on CO2 ventilatory response

Glauber Santos Ferreira Silva,Humberto Giusti,Wagner Luis Reis,Mirela Barros Dias,Luciane H. Gargaglioni,Luiz G.S. Branco+1 more-2008-04-01-The FASEB Journal
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TL;DRAbstract

Background: Several brainstem regions have been recognized as central CO2/pH chemoreceptors, including the medullary raphe region. The specific role of the Nucleus Raphe Obscurus (ROb) in the ventilatory responses to hypercapnia is uncertain, but a prior study suggest that the ROb does not by itself contribute to chemoreception directly, but it has a modulatory role (Li et al., 2006). In the present study, we investigated the involvement of ROb in the ventilatory responses to CO2 by nonspecific lesioning of this nucleus. Methods: Seven days before the experiments, male Wistar rats received microinjections of ibotenic acid (0.4 ìg/0.2 ìL) or vehicle (PBS, 50 mM, pH 7.4) into the ROb. Measurements of ventilation (VE) were performed by the body plethysmograph. Animals were exposed first to humidified room air, followed by 30 min of hypercapnia exposure (7% CO2). Results: Hypercapnia caused hyperventilation and in all groups. ROb lesions decreased ventilatory response to hypercapnia up to

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Background: Several brainstem regions have been recognized as central CO2/pH chemoreceptors, including the medullary raphe region. The specific role of the Nucleus Raphe Obscurus (ROb) in the ventilatory responses to hypercapnia is uncertain, but a prior study suggest that the ROb does not by itself contribute to chemoreception directly, but it has a modulatory role (Li et al., 2006). In the present study, we investigated the involvement of ROb in the ventilatory responses to CO2 by nonspecific lesioning of this nucleus. Methods: Seven days before the experiments, male Wistar rats received microinjections of ibotenic acid (0.4 ìg/0.2 ìL) or vehicle (PBS, 50 mM, pH 7.4) into the ROb. Measurements of ventilation (VE) were performed by the body plethysmograph. Animals were exposed first to humidified room air, followed by 30 min of hypercapnia exposure (7% CO2). Results: Hypercapnia caused hyperventilation and in all groups. ROb lesions decreased ventilatory response to hypercapnia up to

Keywords

HypercapniaNucleus raphe magnusHyperventilationChemoreceptorRaphe nucleiTidal volumeVentilation (architecture)Normocapnia

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