Stress urinary incontinence in women : Pathophysiological aspects

TL;DRAbstract

<p>Objective: The pathophysiology of female stress urinary incontinence (SUI) is multifactorial. In this thesis biochemical and ultrastructural changes in the paraurethral supporting connective tissue and changes in the innervation of the vaginal wall in relation to SUI have been focused upon.</p><p>Methods: Skin and paraurethral biopsies were obtained from pre- and postmenopausal SUI women, with or without estrogen replacement therapy (ERT) and from comparable healthy women. Collagen and proteoglycan composition and concentration were analysed. The mRNA levels for collagens I and III, the small proteoglycans decorin and biglycan, and the large proteoglycan versican were quantified. Difference in collagen metabolism in skin biopsies between comparable SUI and continent women was also analysed. The ultrastructure of the collagen was examined with transmission electron microscopy and the diameters of collagen fibrils were analysed.The immunohistochemical marker protein

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