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Article10.1161/circ.124.suppl_21.a16854

Abstract 16854: Iodine Deficiency and Risk of Coronary Heart Disease Events Among Low Risk Healthy US Adults

Sandip Zalawadiya,Vikas Veeranna,Krithi Ramesh,Ashutosh Neeraj,Luis Afonso,Nandalal Bagchi-2011-11-22-Circulation
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TL;DRAbstract

Background: Prevalence of iodine deficiency (ID) has increased among general US population. No study has evaluated ID's effect on primary risk of coronary heart disease (CHD) events. Objective: Evaluate the relationship between ID and CHD risk Design: Cross-sectional Methods: We evaluated 10,037 adults, free of cardiovascular disease and diabetes, participating in National Health and Nutrition Examination Surveys . Participants were assigned Framingham risk score (FRS) per Adult Treatment Plan guidelines. Urine iodine levels (mcg/L) were used to define ID per World Health Organization criteria: Group 1 -: None(≥100), Group 2 -: Mild(50-99) and Group 3 -: Moderate-severe(<50). Multivariate regression analysis was performed to analyze the effect of ID on the risk of having higher FRS. Results: Mean FRS increased with higher degrees of ID (Group 1: 7.5±8.1 vs Group 3: 9.4±7.4, p<0.001). ID significantly predicted (p<0.001) higher FRS after adjusting for race, body mass index, his

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Background: Prevalence of iodine deficiency (ID) has increased among general US population. No study has evaluated ID's effect on primary risk of coronary heart disease (CHD) events. Objective: Evaluate the relationship between ID and CHD risk Design: Cross-sectional Methods: We evaluated 10,037 adults, free of cardiovascular disease and diabetes, participating in National Health and Nutrition Examination Surveys . Participants were assigned Framingham risk score (FRS) per Adult Treatment Plan guidelines. Urine iodine levels (mcg/L) were used to define ID per World Health Organization criteria: Group 1 -: None(≥100), Group 2 -: Mild(50-99) and Group 3 -: Moderate-severe(<50). Multivariate regression analysis was performed to analyze the effect of ID on the risk of having higher FRS. Results: Mean FRS increased with higher degrees of ID (Group 1: 7.5±8.1 vs Group 3: 9.4±7.4, p<0.001). ID significantly predicted (p<0.001) higher FRS after adjusting for race, body mass index, his

Keywords

MedicineLifetime riskCoronary heart diseaseInternal medicineDiseaseCardiologyRisk factor

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