Διερεύνηση διεπιφανειακών φαινομένων μεταξύ βακτηρίων και βιοϋλικών

TL;DRAbstract

One of the major problems arising from the use of implants and medical devices and impeding their long-term use is the emergence of nosocomial septic incidents related to infections caused by Coagulase negative staphylococci, most notably by S. epidermidis. The extensive use of antibiotics has resulted in multi-resistant bacterial strains of normal flora, making the need for developing antibacterial biomaterials of great importance. For this purpose it is necessary to study and understand the mechanism of bacterial adhesion to the surface of biomaterials. In this direction, we investigated the influence of the physicochemical interactions between bacteria and materials, the shear rate and their relative contribution on the ability of bacteria to adhere to the biomaterial surface and to activate the ica genes, which are responsible for the production of extracellular polymeric (slime), and in particular for the production of polysaccharide intercellular adhesin (PIA), that mediates cel

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