Pharmacogenetics and chiral aspects of anti-asthma therapy

TL;DRAbstract

Introduction: Asthma is a chronic inflammatory airway disease characterised by recurrent symptoms. The available treatment options for the disease to date are concentrated on symptom control. Treatment responses to most anti-asthma medications show wide variation among populations and individuals. There is evidence that genetic variations can affect the pharmacokinetic and pharmacodynamic effects of medications, hence influencing treatment outcomes. The objective of this research is to investigate the effect of some common genetic variations in enzymes and proteins associated with the pharmacokinetic and pharmacodynamic properties of anti-asthma medications. Method: Observational studies were first carried out to examine plasma levels of salbutamol enantiomers during disease exacerbation. Animal models were then employed to study the distribution of salbutamol enantiomers into various tissues and the role of the organic cation transport (OCT) system. The genetic determinants (single nu

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