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Article10.1161/circ.126.suppl_21.a19348

Abstract 19348: The Impact of Hypothyroidism on Platelet-Fibrin Clot Characteristics in Patients Undergoing Cardiac Catheterization

Anand Singla,Kevin P. Bliden,Udaya S. Tantry,Young‐Hoon Jeong,Paul A. Gurbel-2012-11-20-Circulation
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TL;DRAbstract

Hypothyroidism and accompanying hypercholesterolemia are associated with accelerated atherosclerosis. Hypothyroidism has been associated with inflammation, endothelial dysfunction, and platelet function abnormalities. However, impact of hypothyroidism on the physical characteristics of the platelet-fibrin clot is unknown. We sought to determine the impact of hypothyroidism on platelet-fibrin clot characteristics in patients undergoing cardiac catheterization. Methods: Patients on 325 mg daily aspirin with (n=41) and without (n=286) a history of hypothyroidism undergoing cardiac catheterization were studied. Hypothyroidism was defined as treatment with thyroid hormone replacement. Blood samples were collected immediately prior to coronary angiography to determine clotting characteristics by thrombelastography (TEG). Urinary 11-dehydrothromboxane B 2 was performed by immunoassay method. Results: Baseline demographics and cardiac risk factors were similar between groups. Thyroid stimulatin

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Hypothyroidism and accompanying hypercholesterolemia are associated with accelerated atherosclerosis. Hypothyroidism has been associated with inflammation, endothelial dysfunction, and platelet function abnormalities. However, impact of hypothyroidism on the physical characteristics of the platelet-fibrin clot is unknown. We sought to determine the impact of hypothyroidism on platelet-fibrin clot characteristics in patients undergoing cardiac catheterization. Methods: Patients on 325 mg daily aspirin with (n=41) and without (n=286) a history of hypothyroidism undergoing cardiac catheterization were studied. Hypothyroidism was defined as treatment with thyroid hormone replacement. Blood samples were collected immediately prior to coronary angiography to determine clotting characteristics by thrombelastography (TEG). Urinary 11-dehydrothromboxane B 2 was performed by immunoassay method. Results: Baseline demographics and cardiac risk factors were similar between groups. Thyroid stimulatin

Keywords

MedicineCardiac catheterizationFibrinCardiologyPlateletInternal medicineClot formation

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