New glycosylated materials for lectin inhibition, detection and targeting

TL;DRAbstract

The growing knowledge of the biological role played by the glycoside cluster effect and the growing interest in new biocompatible nanomaterials prompted us to synthesize new glycosylated compounds and assemble new glycosylated materials able to recognize specific lectins with inhibition, detection and targeting purposes. These recognition processes, that take place through carbohydrate-protein interactions and are characterized by high selectivity and efficiency, combine a multivalent presentation of carbohydrates and the characteristic of the materials, such as monolayers on gold nanopaticles (AuNPs) and surfaces or the self-assembly properties of particular luminescent complexes. Calixarenes were chosen as privileged scaffolds to functionalize such materials because they offer the unique opportunity to easily tune the valency, the shape and structure of the multivalent carbohydrate presentation. In this Ph.D. thesis concerns we describe a binding study of some new galactosyl- and lac

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