Generation and characterisation of plant produced recombinant antibodies specific to LHRH for treatment of sex hormone dependent diseases

TL;DRAbstract

Leutinising hormone releasing hormone (LHRH) is a hypothalamic neurohormone that plays a pivotal role in the endocrine control of reproduction. Acting through its high affinity receptors on pituitary gonadotrophs, it regulates the secretion of gonadotropins. Manipulation of the neuroendocrine cascade by LHRH intervention leads to the down regulation of sex steroid levels resulting in a state of pharmacological castration, a physiological state useful for treatment of sex hormone dependent diseases. The neuroendocrine axis can be obliterated by synthetic LHRH analogues or by neutralising anti-LHRH antibodies. While the LHRH analogues require frequent dose administration and are expensive, active vaccination against LHRH is limited by the variation in the immune response from patient to patient and the lag period in the build-up of effective antibody titres. The aim of this project was the generation of recombinant anti-LHRH antibodies and their expression in plants for use in passive im

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