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Article10.1080/10426509408018400

α-SUBSTITUIERTE PHOSPHONATE. 70<sup>1</sup>UNTERSUCHUNGEN ÜBER METHYLTHIOMETHANBISPHOSPHORYLDERIVATE

Burkhard Costisella,Sigrid Ozegowski,Hans Groß-1994-01-01-Phosphorus, sulfur, and silicon and the related elements
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TL;DRAbstract

Abstract Thiophilic reaction of ethyl diphenylphosphinite with phosphonodithioformate 1 gave the ylid 9, which could be transformed with HCl to the bisphosphorylcompound 10. Chlorine reacted with 9 to the chlorinated bisphosphorylderivative 12b, with the ylid 2 analogously 12a was formed. With BTMS/H2O 10 could be dealkylated to the acid 11b, the bisphosphonate 3 in similar way to 11a. Using the Hornermethod 3 was transformed to the methylthiovinylphosphonates 17, which could be converted to the acids 18 using the BTMS/H2O-method.

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Abstract Thiophilic reaction of ethyl diphenylphosphinite with phosphonodithioformate 1 gave the ylid 9, which could be transformed with HCl to the bisphosphorylcompound 10. Chlorine reacted with 9 to the chlorinated bisphosphorylderivative 12b, with the ylid 2 analogously 12a was formed. With BTMS/H2O 10 could be dealkylated to the acid 11b, the bisphosphonate 3 in similar way to 11a. Using the Hornermethod 3 was transformed to the methylthiovinylphosphonates 17, which could be converted to the acids 18 using the BTMS/H2O-method.

Keywords

PhosphonateChlorineChemistryChlorine atomMedicinal chemistryStereochemistryOrganic chemistry

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