The impact of transforming growth factor beta 1 on dendritic cell development and subset specification

TL;DRAbstract

Dendritic cells (DC) are bone marrow-derived antigen presenting cells that are crucial for inducing adaptive immune responses and maintaining T cell tolerance. An increasingly precise picture of DC development from bone marrow progenitors is emerging, including the discovery of a DC lineage restricted common DC progenitor (CDP). The molecular mechanisms determining DC commitment of CDP and their further specification into DC subsets remained, however, less clear. This is partly due to the lack of genetic tools and/or culture model systems that would allow the developmental stage-specific analysis of the impact of single factors, like transcription factors and cytokines, on DC development. In this study, I have developed a culture system that reproduces CDP in vitro and addressed the molecular mechanisms behind DC commitment of CDP from multipotent progenitors (MPP). The in vitro amplified CDP recapitulate the function, surface marker and gene expression profile of in vivo CDP, therefor

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