Abstract TP440: The Discriminant Validity of the NINDS-CSN Harmonization Neurocognitive Battery in Detecting VCI in Singaporean Patients with Ischemic Stroke and TIA

TL;DRAbstract

Background: An international standard for the diagnosis of Vascular Cognitive Impairment (VCI) is currently in development. We report preliminary findings of Singaporean contribution to theNINDS-Canadian Stroke Network (NINDS-CSN) neuropsychological protocol harmonization study. Purpose: We examined the discriminant validity of 3 neuropsychological protocols (60 Minute (M), 30M and 5M) by comparing cognitive performance of patients with stroke and TIA to cognitively normal controls. Methods: Patients (≥50 years old) with stroke or TIA and the controls were administered the NINDS-CSN harmonization neurocognitive battery by trained psychometricians blinded to the group status of the patients or controls. ANCOVA was conducted to compare the between group cognitive performance. ROC analyses were employed to examine the ability of the 3 protocols and the cognitive domains of the 60M protocol in discriminating patients with ischemic stroke or TIA from the controls. Results: 52 patients and 6

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