TL;DRAbstract
In the other chapters in this book, it is apparent that bone is the tissue that is affected during periods of inadequate dietary calcium intake, as a result of changes in physiology or defects in calcium homeostasis. Based on this, one might reasonablybut incorrectly—believe that calcium homeostasis is regulated to maintain bone integrity. As Fig. 1 illustrates, and as Chapter 10 developed in some detail, bone, intestine, and kidney make up a three-tissue axis whose activities are coordinated to maintain serum calcium within a narrow range (8.9–10.2 mg/dL). In this model, calcium absorption from the intestine is a disturbing signal that elevates serum calcium after a meal while turnover (i.e., the balance between bone formation and resorption) and renal calcium excretion are controlling signals that respond to fluxes in serum calcium. The import of this coordinated regulation can be seen in the table accompanying Fig. 1. This table is based on research by Bronner and Aubert who studied
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In the other chapters in this book, it is apparent that bone is the tissue that is affected during periods of inadequate dietary calcium intake, as a result of changes in physiology or defects in calcium homeostasis. Based on this, one might reasonablybut incorrectly—believe that calcium homeostasis is regulated to maintain bone integrity. As Fig. 1 illustrates, and as Chapter 10 developed in some detail, bone, intestine, and kidney make up a three-tissue axis whose activities are coordinated to maintain serum calcium within a narrow range (8.9–10.2 mg/dL). In this model, calcium absorption from the intestine is a disturbing signal that elevates serum calcium after a meal while turnover (i.e., the balance between bone formation and resorption) and renal calcium excretion are controlling signals that respond to fluxes in serum calcium. The import of this coordinated regulation can be seen in the table accompanying Fig. 1. This table is based on research by Bronner and Aubert who studied
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