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Molecular Investigations of the Common Mitochondrial Deletion (MTDNA 49777) Tumoral Tissues as Compared with Adjacent Non-Tumoral Tissues from Gastric Cancer Patients at Baghiyatallah Hospital in Tehran

Behnam Kamalıdehghan-2007-01-01-Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)
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TL;DRAbstract

The human mitochondrial genome has been completely sequenced and each gene has been identified and characterized. The human mtDNA is a supercoiled, double-stranded circular molecule of 16,569 base pairs in size which codes for 13 of the 87 proteins required for oxidative phosphorylation as well as the 12s and 16s rRNAs and 22 tRNAs required for protein synthesis in the mitochondria. One of the common regions and hot spot of the mitochondrial genome so-called the common mitochondrial deletion (AmtDNA4977) was investigated which is at nucleotide number 8470 to 13447. This deletion affects important genes, involved in - OXPHOS (Oxidative Phosphorylation) such as ATPase 6, ATPase 8, Cytochrome Oxidase 111, and NADH subunits ND3, ND4, ND4L, and ND5 which may have a strong metabolic disadvantage. The prevalence of the AmtDNA4977 deletion has been investigated in different cancers. However in this study, we screened the common mitochondrial deletion to determine the prevalence of the common m

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The human mitochondrial genome has been completely sequenced and each gene has been identified and characterized. The human mtDNA is a supercoiled, double-stranded circular molecule of 16,569 base pairs in size which codes for 13 of the 87 proteins required for oxidative phosphorylation as well as the 12s and 16s rRNAs and 22 tRNAs required for protein synthesis in the mitochondria. One of the common regions and hot spot of the mitochondrial genome so-called the common mitochondrial deletion (AmtDNA4977) was investigated which is at nucleotide number 8470 to 13447. This deletion affects important genes, involved in - OXPHOS (Oxidative Phosphorylation) such as ATPase 6, ATPase 8, Cytochrome Oxidase 111, and NADH subunits ND3, ND4, ND4L, and ND5 which may have a strong metabolic disadvantage. The prevalence of the AmtDNA4977 deletion has been investigated in different cancers. However in this study, we screened the common mitochondrial deletion to determine the prevalence of the common m

Keywords

Mitochondrial DNABiologyMolecular biologyHuman mitochondrial geneticsCancerHypervariable regionMitochondrionGene

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