A Programmable Long Term Electrical Stimulation System for Cell Cultures on Microelectrode Arrays

TL;DRAbstract

Microelectrode arrays (MEAs) provide a means for measuring the electrical activity of cell cultures and their electrical stimulation locally, but their viability for long term stimulation of entire cultures is limited at best. For this purpose, a novel platform for electrically stimulating excitable cells on MEAs in long term cell culturing was devised. The designed and implemented system is a programmable electrical stimulation platform, capable of producing different kinds of electrical stimuli for several days on its own in a controlled environment, such as an incubator.\n\nThe system consists of three parts: a MEA container with stimulation electrodes, electronics for creating and amplifying the stimulation signal and a software designed for controlling the stimulus on a personal computer. Apart from the waveform generator and the personal computer, all aspects of the device were designed and built for this thesis. This work is a part of Stemfunc, an Academy of Finland funded proje

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