乳腺癌c-erbB-2的表达及其与临床病理指标的关系

TL;DRAbstract

Objective To observe the expression of c-crhB-2 and its relationships with clinicopathological parameters including estrogen receptor (ER), progestogen receptor (PR), axillary lymph node metastasis, tumor size and pathological type. Methods We collected data from the 912 primary breast cancer cases who had not undergone adjuvant therapy. The expression of c-erbB-2 was measured by immunohistochemistry (IHC). Then we analyzed the correlation of c-erbB-2 expression with age, tumor size, clinical staging, tumor site, menopause status, axillary lymph node, ER, PR and pathological classification as well as the connection between c-erbB-2 expression and prognosis in using follow-up data. Results The total positive rate of c-erbB-2 was 23.0%. There were significant differences in c-erbB-2 expression among different age groups (P=0.009), especially between those under 35 years old and those above 55 years old (P=0.006); tumor diameter＜2cm, 2-5cm and＞5cm groups (P＜0.01), with the positive rate i

Chat with Paper

AI Agents for this Paper