Receptors for Coxsackieviruses and Echoviruses

TL;DRAbstract

Studies in the late 1950s demonstrated that homogenates of particular tissues could adsorb picornaviruses, including some echoviruses and coxsackieviruses, and correlated virus adsorption with susceptibility to infection. The understanding of the receptors for group B coxsackieviruses (CVBs) is largely based on work carried out in the beginning of 1960s, and culminating in the identification of two receptor molecules within the past 5 years. Attachment-interference studies, in which saturation of cellular receptors by one virus was found to prevent attachment of a related virus, identified several picornavirus receptor families, whose members were likely to share receptors. Decay-accelerating factor (DAF) is expressed on many cell types and functions to protect cells from lysis by autologous complement. DAF is a member of a family of complement regulatory proteins composed of homologous short consensus repeat (SCR) domains. Consistent with the original observation that all six CVB sero

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