Carbimazole induced acute generalised exanthematous pustulosis

TL;DRAbstract

Acute generalised exanthematous pustulosis (AGEP) also known as pustular drug eruption is an unusual drug induced hypersensitivity skin manifestation, characterized by acute onset of fever, and numerous non-follicular pin-head sterile pustules on erythematous background, usually over the flexural areas and face [1]. Neutrophils are involved in the pathogenesis of AGEP. Neutrophil-activating cytokines like IL-3 and IL-8 have been implicated [2]. Around 90 percent of the times AGEP is caused by a drug. Reported most often due to antibacterials. Carbimazole which is a thiourea antithyroid drug is not one of the usual suspect. We report a case of a 50-year-old man with history of chronic diarrhea since 2 years, subsequently diagnosed as hyperthyroidism, without a previous history of psoriasis, developed a widespread, pin head pustular eruption on the face and extremities 48 hours after starting carbimazole for hyperthyroidism. His blood investigations revealed neutrophilic leucocytosis. Th

Chat with Paper

AI Agents for this Paper