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Article10.1118/1.4924374

SU‐E‐T‐13: A Comparative Dosimetric Study On Radio‐Dynamic Therapy for Pelvic Cancer Treatment: Strategies for Bone Marrow Dose and Volume Reduction

C Li,B Wang,Zheng Dong,Wei Ge,Liming Xu,Chong‐Bo Ma-2015-06-01-Medical Physics
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TL;DRAbstract

Purpose: Radio‐dynamic therapy (RDT) is a potentially effective modality for local and systemic cancer treatment. Using RDT, the administration of a radio‐sensitizer enhances the biological effect of high‐energy photons. Although the sensitizer uptake ratio of tumor to normal tissue is normally high, one cannot simply neglect its effect on critical structures. In this study, we aim to explore planning strategies to improve bone marrow sparing without compromising the plan quality for RDT treatment of pelvic cancers. Methods: Ten cervical and ten prostate cancer patients who previously received radiotherapy at our institution were selected for this study. For each patient, nine plans were created using the Varian Eclipse treatmentplanning‐system (TPS) with 3D‐CRT, IMRT, and VMAT delivery techniques containing various gantry angle combinations and optimization parameters (dose constraints to the bone marrow). To evaluate the plans for bone marrow sparing, the dose‐volume parameters V5, V

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Purpose: Radio‐dynamic therapy (RDT) is a potentially effective modality for local and systemic cancer treatment. Using RDT, the administration of a radio‐sensitizer enhances the biological effect of high‐energy photons. Although the sensitizer uptake ratio of tumor to normal tissue is normally high, one cannot simply neglect its effect on critical structures. In this study, we aim to explore planning strategies to improve bone marrow sparing without compromising the plan quality for RDT treatment of pelvic cancers. Methods: Ten cervical and ten prostate cancer patients who previously received radiotherapy at our institution were selected for this study. For each patient, nine plans were created using the Varian Eclipse treatmentplanning‐system (TPS) with 3D‐CRT, IMRT, and VMAT delivery techniques containing various gantry angle combinations and optimization parameters (dose constraints to the bone marrow). To evaluate the plans for bone marrow sparing, the dose‐volume parameters V5, V

Keywords

MedicineBone marrowRadiation therapyProstate cancerRadiation treatment planningNuclear medicineCervical cancerProstate

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